Tranexamic Acid Has a Limited Role in Improving Visual Clarity and Pain in Arthroscopic Shoulder Surgery: A Systematic Review and Meta-Analysis
Related Experiment Video
Updated: May 21, 2025
Knee Arthrocentesis in Adults
Published on: February 25, 2022
Danielle Dagher1, Imad Kashir1, Osman Mahboob2
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Purpose:
To evaluate the effects of tranexamic acid (TXA) compared with placebo or other comparators regarding visual clarity, pain, total operative time, and volume of blood loss in patients undergoing arthroscopic shoulder surgery.
Methods:
CENTRAL, EMBASE, and MEDLINE were searched from inception until January 4, 2025. Study selection and data extraction were carried out in duplicate. Randomized controlled trials that compared TXA with placebo or another comparator in patients undergoing arthroscopic shoulder surgery were included. All outcomes were assessed in duplicate for risk of bias (RoB) using the RoB 2 tool and for certainty of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach. Results were pooled in a meta-analysis using a random-effects model when appropriate or were synthesized narratively when data could not be pooled. Overall, 12 randomized controlled trials involving 1,009 patients were included.
Results:
The pooled estimate for visual clarity shows a slight increase in visual clarity (standardized mean difference 0.64 [0.05, 1.24]). The pooled estimate for pain shows a mean difference of a reduction of pain by 0.38 points in the TXA group on a visual analog scale of 0 to 10 (0 = no pain) (mean difference -0.38 [-0.76, 0.00]).
Conclusions:
There is moderate-certainty evidence suggesting that TXA likely results in a slight increase in visual clarity. The evidence also suggests that TXA has little to no difference in pain, operative time, and volume of blood loss.
Level Of Evidence:
Level I, Systematic Review of Level I Studies.
