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Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies

Bushra Bashir1, Pranshul Sethi2, Satyajit Panda3

  • 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144402, India.

Cellular Signalling
|March 19, 2025
PubMed

Insights

Cancer involves epigenetic changes, not just genetic mutations. Phytomedicine, using natural products and nanotechnology, offers promising epigenetic therapy avenues for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Epigenetic mechanisms are vital for normal gene expression and tissue development.
  • Disruptions in epigenetics contribute to cellular transformation and malignancy, defining cancer.
  • Cancer exhibits widespread epigenetic landscape alterations, including DNA methylation and histone modifications.

Purpose of the Study:

  • To review the epigenetic link between cancer and phytomedicine treatment mechanisms.
  • To explore natural products as a source for epigenetic therapeutics.
  • To discuss nanotechnology and strategies for overcoming challenges in developing phytomedicine-based epigenetic drugs.

Main Methods:

  • Comprehensive literature review on cancer epigenetics and phytomedicine.
  • Analysis of molecular targets of natural products in epigenetic regulation.
  • Evaluation of nanotechnology applications in epigenetic drug delivery.

Main Results:

  • Epigenetic reprogramming is a hallmark of cancer, involving DNA methylation, histone modifications, nucleosome positioning, and non-coding RNAs.
  • Phytomedicine offers potential therapeutic strategies by targeting these epigenetic mechanisms.
  • Natural products show diverse molecular targets for epigenetic drug discovery.

Conclusions:

  • Understanding epigenetic alterations in cancer is crucial for developing novel therapies.
  • Phytomedicine presents a promising avenue for epigenetic cancer treatment.
  • Further research into natural products, nanotechnology, and clinical strategies is needed to advance epigenetic therapy.
Keywords:
Aging, epigeneticsCancerDNA damageEpigeneticsPhytomedicine

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