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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Ovarian Cycle

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Disorders of the Female Reproductive System

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Sexually Transmitted Infections

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Histology of the Uterus

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The endometrium is the...
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Mitral Valve Prolapse III: Nursing Management

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Related Experiment Video

Updated: Jul 19, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
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Managing concurrent endometrial stromal sarcoma during pregnancy.

Sarah Black1, Kalpana Ragupathy2, Kirsty McNeil3

  • 1University of Dundee School of Medicine, Dundee, UK Sarah.black9@nhs.scot.

BMJ Case Reports
|March 19, 2025
PubMed
Summary

This case study details a rare instance of low-grade endometrial stromal sarcoma co-occurring with pregnancy. It highlights diagnostic challenges and multidisciplinary management, supporting the patient's wish to continue the pregnancy.

Keywords:
Gynecological cancerPregnancy

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Area of Science:

  • Gynecologic Oncology
  • Reproductive Medicine
  • Oncology

Background:

  • Endometrial stromal sarcoma (ESS) co-occurring with pregnancy is exceptionally rare.
  • Limited research exists on managing this dual condition, complicating diagnosis and treatment.
  • This case involves a low-grade ESS diagnosed during early gestation.

Purpose of the Study:

  • To report a rare case of low-grade endometrial stromal sarcoma diagnosed during pregnancy.
  • To discuss the diagnostic challenges and multidisciplinary management strategies employed.
  • To emphasize the importance of supporting patient autonomy in complex obstetric-oncologic scenarios.

Main Methods:

  • A case report detailing a pregnant patient with suspected pyelonephritis.
  • Diagnostic workup included serial imaging, specifically Magnetic Resonance Imaging (MRI).
  • Multidisciplinary team approach involving obstetrics, gynecology, radiology, and oncology.

Main Results:

  • MRI revealed a pelvic mass consistent with ESS, invading pelvic veins and compressing the ureter.
  • The patient experienced obstructive uropathy secondary to tumor compression.
  • The diagnosis and management plan were tailored to accommodate the ongoing pregnancy.

Conclusions:

  • Co-occurrence of ESS and pregnancy presents significant diagnostic and management hurdles.
  • Multidisciplinary collaboration is crucial for optimal patient care in such rare cases.
  • Supporting the patient's decision to continue the pregnancy is paramount when medically feasible.