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Polymer-Mediated Delivery of Amphotericin B for Fungal Infections

Yongnan Chen1, Fang Liu1, Qiao Jin1,2

  • 1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, China.

Macromolecular Rapid Communications
|March 19, 2025
PubMed

Insights

Polymer-based delivery systems offer a promising solution to improve the effectiveness of Amphotericin B (AmB), a key antifungal drug. These advanced strategies aim to reduce AmB

Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Science
  • Infectious Diseases

Background:

  • Invasive fungal infections pose a significant global health threat with high mortality rates.
  • Amphotericin B (AmB) is a crucial antifungal agent but is limited by severe side effects and poor bioavailability.
  • Polymers offer versatile platforms for developing advanced drug delivery systems.

Purpose of the Study:

  • To review recent advancements in polymer-based delivery systems for Amphotericin B (AmB).
  • To highlight strategies for mitigating AmB's toxicity and enhancing its therapeutic efficacy.
  • To discuss the future prospects of polymer-drug conjugates, nanoparticles, hydrogels, and microneedles for antifungal therapy.

Main Methods:

  • Comprehensive literature review of polymer-based Amphotericin B delivery systems.
  • Analysis of various polymeric formulations including conjugates, nanoparticles, hydrogels, and microneedles.
  • Evaluation of studies focusing on improved bioavailability and reduced toxicity of AmB.

Main Results:

  • Polymer-based strategies demonstrate potential in enhancing Amphotericin B's bioavailability.
  • Formulations like polymeric nanoparticles and conjugates show promise in reducing AmB-associated side effects.
  • Diverse polymer architectures enable tailored delivery for improved antifungal treatment.

Conclusions:

  • Polymer-based delivery systems represent a significant advancement in overcoming Amphotericin B's limitations.
  • These innovative approaches are crucial for developing safer and more effective treatments for invasive fungal infections.
  • Further research into novel polymer designs and delivery mechanisms is warranted for optimized antifungal therapy.
Keywords:
amphotericin Bdrug deliveryfungal infectionspolymer

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