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Toward real-time margin assessment in breast-conserving surgery with hyperspectral imaging
Lynn-Jade S Jong1,2, Dinusha Veluponnar1,2, Freija Geldof1
1Image-Guided Surgery, Department of Surgery, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.
Scientific Reports
|March 20, 2025
Summary
Hyperspectral imaging (HSI) offers a rapid, non-invasive method for assessing breast-conserving surgery margins. This technique accurately identifies tumor tissue, potentially reducing re-operations and improving patient outcomes.
Area of Science:
- Medical imaging
- Surgical oncology
- Biophotonics
Background:
- Accurate margin assessment is crucial in breast-conserving surgery (BCS) to prevent local recurrence.
- Current methods for margin assessment are time-consuming and can lead to inadequate tumor resection in 20-25% of cases.
Purpose of the Study:
- To evaluate the diagnostic performance of hyperspectral imaging (HSI) for non-invasive margin assessment in ex vivo breast lumpectomy specimens.
- To determine the feasibility of HSI as a tool for real-time intraoperative margin evaluation.
Main Methods:
- A dataset of over 200 lumpectomy specimens was acquired using two hyperspectral cameras.
- A classification algorithm was developed to differentiate healthy tissue from tumor tissue within 0 and 2 mm margins.
- The entire resection surface was imaged and analyzed within 10 minutes.
Main Results:
- The HSI approach demonstrated high diagnostic performance, particularly at a 0 mm margin.
- Sensitivity reached 92%, specificity 78%, accuracy 83%, with an AUC of 89% at a 0 mm margin.
- Rapid assessment (under 10 minutes) was achieved for the entire resection surface.
Conclusions:
- Hyperspectral imaging presents a promising, rapid, and non-invasive alternative for assessing surgical margins in BCS.
- This technology has the potential to enhance surgical precision and significantly decrease re-excision rates.
