Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disulfiram hepatitis.

S J Morris1, R Kanner, R O Chiprut

  • 1Department of Medicine, Veterans Administration Hospital, Miami, Florida 33125.

Gastroenterology
|July 1, 1978
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sacral nerve stimulation in patients with slow transit constipation.

Techniques in coloproctology·2019
Same author

Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease.

Human genetics·2018
Same author

Integrated total pelvic floor ultrasound in pelvic floor defaecatory dysfunction.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2016
Same author

Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection.

Journal of viral hepatitis·2015
Same author

Design and implementation of a new autonomous sensor fish to support advanced hydropower development.

The Review of scientific instruments·2014
Same author

Long-term clearance of hepatitis C virus following interferon α-2b or peginterferon α-2b, alone or in combination with ribavirin.

Journal of viral hepatitis·2013
Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026
Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026
Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026
Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026
Same journal

Epithelial FOXP3 orchestrates O-glycosylated IL-6 secretion to drive pancreatic fibrocarcinogenesis.

Gastroenterology·2026
Same journal

Reply to "Methodological Considerations on Neonatal Metabolomics and Future Inflammatory Bowel Disease".

Gastroenterology·2026
See all related articles

Disulfiram can cause drug-induced hepatitis in adults. Promptly screening liver chemistries before and during disulfiram therapy is crucial for early detection and management of liver injury.

Area of Science:

  • Hepatology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Disulfiram is a medication used to deter alcohol consumption.
  • Hepatotoxicity is a potential adverse effect of disulfiram therapy.
  • Distinguishing drug-induced liver injury from alcohol-related liver disease can be challenging.

Observation:

  • A case study of an adult patient experiencing disulfiram-induced hepatitis is presented.
  • The patient exhibited signs of hepatocellular damage.
  • Liver damage was reversible upon discontinuation of disulfiram.

Findings:

  • A provocative challenge confirmed disulfiram's etiological role in the patient's hepatitis.
  • Hepatocellular damage was evidenced by abnormal liver chemistries.

Related Experiment Videos

  • Withdrawal of disulfiram led to the resolution of liver injury.

    • Implications:

    • Disulfiram-induced liver injury requires careful monitoring, especially in populations with high rates of alcohol-related liver disease.
    • Pre-treatment screening of liver chemistries is recommended before initiating disulfiram.
    • Periodic monitoring of liver function during disulfiram treatment is essential for patient safety.