Related Experiment Video
Updated: May 21, 2025
12:21
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
Published on: November 30, 2013
14.9K
lncRNA TUG1 and kidney diseases
Tong Chen1, Jian Lu1, Qiuling Fan2
1Department of Nephrology, Shenyang Seventh People's Hospital, Shenyang, 110003, Liaoning, China.
BMC Nephrology
|March 20, 2025
Summary
Long noncoding RNA (lncRNA) TUG1 shows protective effects in diseases by inhibiting apoptosis and inflammation. This review explores TUG1
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Long noncoding RNAs (lncRNAs) are crucial regulators of gene expression and cellular processes.
- Taurine-upregulated gene 1 (TUG1) is a lncRNA identified for its protective roles against cellular damage.
- TUG1 has demonstrated potential in inhibiting apoptosis and inflammatory responses.
Purpose of the Study:
- To review the recent advancements in understanding lncRNA TUG1's role in kidney diseases.
- To elucidate the molecular mechanisms underlying TUG1's function in renal pathology.
Main Methods:
- Literature review of studies on TUG1 and kidney diseases over the past 8 years.
- Analysis of molecular pathways involving TUG1 in cellular and disease models.
Main Results:
- TUG1 plays a significant role in various kidney diseases.
- TUG1 influences apoptosis, inflammation, and mitochondrial function in kidney cells.
- TUG1's therapeutic potential in kidney disease is supported by emerging evidence.
Conclusions:
- lncRNA TUG1 is a key player in the pathogenesis and progression of kidney diseases.
- TUG1 represents a promising therapeutic target for kidney disease intervention.
- Further research into TUG1's mechanisms can lead to novel treatment strategies.
More Related Videos
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
01:10Nephrons
1.9K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.9K
03:18Non-LTR Retrotransposons
11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K
01:12Loss of Tumor Suppressor Gene Functions
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.7K
03:03mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
01:31Translation
14.3K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
Translation Produces the Building Blocks of Life
Proteins are...
14.3K