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Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential
Reema Mishra1, Preeti Agarwal1, Anshita Sharma1
1Department of Botany, Gargi College, University of Delhi, New Delhi, India.
Protein and Peptide Letters
|March 20, 2025
Summary
Plant-derived cyclotides show promise for treating immune disorders. A modified cyclotide, [T20K], effectively reduced symptoms and mortality in mouse models of autoimmune disease.
Area of Science:
- Immunology and Pharmacology
- Natural Product Chemistry
Background:
- Immune-related disorders are increasing globally, with current treatments having limitations.
- Cyclotides, stable plant-derived cyclic peptides, possess inherent stability and membrane-penetrating properties.
- Their immunomodulatory potential makes them candidates for treating immune disorders.
Purpose of the Study:
- To review the current research and future implications of cyclotides in treating immune-related disorders.
- To highlight the therapeutic potential of cyclotides as immunomodulatory agents.
Main Methods:
- Review of existing literature on cyclotides and their immunomodulatory activities.
- Analysis of preclinical and in vivo studies on native and modified cyclotides, including [T20K] and grafted cyclotides.
Main Results:
- Limited native cyclotides have been screened for immunomodulatory activity.
- The synthetic mutant [T20K] demonstrated significant reduction in cytokine secretion, demyelination, and inflammation in mouse models.
- [T20K] showed improved survival rates compared to conventional immunosuppressive drugs.
Conclusions:
- Cyclotides, particularly modified versions like [T20K], hold significant therapeutic potential for immune-related disorders.
- Further research into cyclotides could lead to novel treatments for autoimmune diseases.
- Grafting bioactive peptides onto cyclotide scaffolds enhances their therapeutic capabilities.
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