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Updated: May 21, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
Exploring New Horizons in Wound Healing: A Comprehensive Analysis
Saurabh Punia1, Dheeraj Upadhyay1, Pratiksha Srivastava1
1School of Pharmaceutical Sciences, Chhatrapati Shahu Ji Maharaj University, Kanpur, 208024, India.
Abstract:
The physiological process of wound healing is complicated and involves extensive connections between biological, molecular, and cellular pathways. Acute and chronic wounds pose a serious socioeconomic burden by impacting millions of people each year globally, which has significantly increased the problem of amputations, longer hospital stays, and mortality. Despite tremendous progress, in aging populations, associated conditions like diabetes and growing antibiotic resistance make chronic wounds even more clinically challenging. Recent developments in science and technology and research at cellular and molecular levels have opened up new possibilities for wound healing by laying the foundation for new technologies, techniques, and information. This review provides an in-depth knowledge of phases of wound healing, innovative methods, and combining technology for wound repair for successful therapies. This study reveals the associated challenges with wound healing dressings, including traditional, advanced, and biotechnology-based dressings. Moreover, this study also includes herbal remedies for wound repair, wound assessment techniques, and experimental wound healing models. This report additionally includes new treatment technologies, such as smart wound dressings capable of real-time monitoring and delivery of drugs at a controlled rate. Finally, an extremely inventive and futuristic approach that adds a new horizon in wound healing is the use of nanobots, and new analytical tools based on machine learning and artificial intelligence (AI) are also considered.
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