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Published on: April 19, 2024
Remdesivir for the Treatment of Human Coronavirus OC43 Encephalitis
Jacques Fourgeaud1,2, Pascal Turlure3, Marine Dupont4
1Université Paris Cité, URP 7328 FETUS, Paris, France.
Abstract:
Human coronavirus OC43 (HCoV-OC43) is predominantly associated with mild respiratory infections. HCoV-OC43 also has neuroinvasive properties, and severe encephalitis has been described in immunocompromised patients, with fatal outcomes due to the lack of specific antiviral treatment. We report a case of severe febrile encephalitis attributed to HCoV-OC43 that progressively worsened over 3 months in a 65-year-old immunocompromised man. Clinical symptoms improved remarkably after treatment with remdesivir, with an increase of the Glasgow Coma Score from 8 to 14 within 7 days.
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