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Updated: May 21, 2025

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Prasugrel Intermediate Metabolite Modulates Platelet Inhibition by Negatively Interfering With an Active Metabolite:

Pietro Minuz1, Alejandro Giorgetti2, Alessandra Meneguzzi1

  • 1Department of Medicine, Section of Internal Medicine C (P.M., A.M., F. Taus, M. Castelli, C.F.), University of Verona, Italy.

Arteriosclerosis, Thrombosis, and Vascular Biology
|March 20, 2025
PubMed
Summary

Prasugrel’s intermediate metabolite (PIM) antagonizes the active metabolite (PAM), reducing its antiplatelet activity. This finding suggests PIM interferes with P2Y12 inhibition, impacting prasugrel

Keywords:
drug interactionsmyocardial infarctionpharmacokineticsplatelet aggregationprasugrel hydrochloride

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