Related Experiment Video

Updated: May 21, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.8K

Characteristics of children with severe preschool asthma prior to starting the TIPP study

S Zielen1, J Wosniok2, N Wollscheid2

  • 1Department for Children and Adolescents, Goethe-University Frankfurt, Frankfurt, Germany.

Frontiers in Pediatrics
|March 20, 2025
PubMed

Insights

Preschool children with severe asthma often remain uncontrolled despite inhaled corticosteroids (ICS). This study highlights the need for better asthma management strategies in young children, focusing on severe exacerbations and symptom control.

Area of Science:

  • Pediatric Pulmonology
  • Asthma Research
  • Clinical Trials

Background:

  • Preschool children experience more severe asthma exacerbations than school-aged children.
  • Limited data exists on the characteristics, hospitalizations, phenotypes, and symptoms in this young age group.
  • Severe asthma exacerbations in children are defined by systemic steroid use or hospitalization.

Purpose of the Study:

  • To assess baseline characteristics, hospitalizations, and symptoms in children with severe preschool asthma.
  • To analyze data from the Tiotropium bromide in preventing severe asthma exacerbations (TIPP) study.
  • To evaluate asthma control levels in preschool children using GINA guidelines.

Main Methods:

  • Analysis of 100 children aged 1-5 years with severe preschool asthma from the TIPP study.
  • Assessment of baseline characteristics including past exacerbations and the TRACK score.
  • Daily symptom recording using the Pediatric Asthma Caregiver Diary (PACD) for four weeks.

Main Results:

  • Children experienced a mean of 5.8 severe asthma exacerbations in the prior 24 months.
  • At randomization, 58% of children were uncontrolled, 35% partially controlled, and only 7% controlled according to GINA guidelines.
  • The mean TRACK score was 46.9 ± 19.0.

Conclusions:

  • Most preschool children with severe asthma remain uncontrolled or partially controlled, even with inhaled corticosteroids (ICS).
  • This indicates a significant unmet need for improved asthma management in this vulnerable population.
  • Further research is needed to optimize treatment strategies for severe preschool asthma.
Abstract

Keywords:
PACDasthma phenotypeshospitalizationpreschool asthmatiotropium bromideuncontrolled asthma

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.2K
Methodology for Sputum Induction and Laboratory Processing13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.4K

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.4K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
298
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K