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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Quantitative proteomics and applications in covalent ligand discovery.

Ananya A Basu1,2, Xiaoyu Zhang1,2,3,4,5

  • 1Department of Chemistry, Northwestern University, Evanston, IL 60208.

Frontiers in Chemical Biology
|March 20, 2025
PubMed
Summary

Multiplexing technologies in proteomics allow for large-scale protein quantification. This review explores quantitative proteomic techniques crucial for covalent ligand discovery, enhancing selectivity profiling and mechanistic understanding.

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