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Updated: May 21, 2025

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Recent Insights Concerning Autophagy and Endothelial Cell Nitric Oxide Generation
Seul-Ki Park1, Jae Min Cho2,3, Sohom Mookherjee1
1Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
None:
Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.
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