Relationship between weight-to-waist index and post-stroke depression

Area of Science:

• Neurology
• Cardiology
• Metabolic Syndrome

Background:

• The weight-to-waist index (WWI) is an emerging metric for assessing central obesity.
• The association between WWI and post-stroke depression (PSD) is not well-established.

Purpose of the Study:

• To investigate the relationship between WWI and the prevalence of PSD.
• To determine if central obesity, as indicated by WWI, is a risk factor for PSD.

Main Methods:

• Analysis of data from the National Health and Nutrition Examination Survey (2005-2018).
• Utilized multivariable logistic regression and propensity score matching to assess the WWI-PSD association.
• Employed restricted cubic spline analysis to examine non-linear relationships.

Main Results:

• Higher WWI values were significantly associated with an increased risk of PSD (OR=2.21).
• Even after propensity score matching, elevated WWI remained a significant predictor of PSD (OR=1.43).
• A dose-response relationship was observed, with the highest WWI tertile showing the greatest PSD risk.

Conclusions:

• Elevated WWI is significantly associated with a higher risk of developing PSD.
• Routine depression screening in stroke patients with high WWI is advised to improve clinical outcomes.