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Updated: May 21, 2025
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FYN Tyrosine Kinase Gene Polymorphisms in Alcohol-Dependent Korean Patients
Sung Young Huh1, Sung-Gon Kim1,2, Ji-Hoon Kim1,2
1Department of Psychiatry, Pusan National University Yangsan Hospital, 50612 Yangsan, Republic of Korea.
Alpha Psychiatry
|March 20, 2025
Summary
The FYN gene may be linked to alcohol use disorder (AUD). Specific genetic variations in FYN were associated with AUD in Korean males and females, suggesting FYN as a potential genetic factor.
Area of Science:
- Neuroscience
- Genetics
- Pharmacology
Background:
- Alcohol use disorder (AUD) is a prevalent condition with significant economic impact.
- Dysregulation of the glutamate cell signaling pathway is implicated in AUD pathogenesis.
- The FYN gene, involved in NMDA receptor phosphorylation, has been proposed as a potential factor in AUD.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in the FYN gene and alcohol use disorder (AUD).
- To explore potential sex-specific genetic contributions to AUD susceptibility within the Korean population.
Main Methods:
- Genotyping of ten selected FYN gene SNPs in 354 alcohol-dependent individuals and 139 controls from South Korea.
- Utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for SNP analysis.
- Statistical analysis to compare allele and genotype frequencies between AUD patients and control groups.
Main Results:
- Significant differences in genotype and allele frequencies for rs1058134 in male AUD patients compared to controls.
- Significant associations were observed for rs12191154 and rs9387025 in female AUD patients.
- Specific genotypes (GG for rs1058134) and alleles (G for rs1058134) were less frequent in male AUD patients, while others (AA for rs12191154 and rs9387025) were less frequent or more frequent in female AUD patients, respectively.
Conclusions:
- The FYN gene is a potential candidate gene for alcohol use disorder (AUD).
- Identified specific FYN SNPs associated with AUD, indicating a possible genetic predisposition.
- Further research is warranted to elucidate the functional roles of these SNPs and their precise mechanisms in AUD development.
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