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Related Experiment Videos

Relaxinlike bioactivity in pooled human pregnancy serum.

S H Brenner, J B Lessing, R D D'Eletto

    Obstetrics and Gynecology
    |July 1, 1985
    PubMed
    Summary

    This study demonstrates that relaxin in human pregnancy serum is biologically active. Pregnancy serum extract inhibited rat uterine horn contractions, unlike other serum samples.

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    Area of Science:

    • Reproductive biology
    • Endocrinology
    • Biochemistry

    Background:

    • Human pregnancy serum contains immunoreactive relaxin.
    • The biological activity of this serum-derived relaxin has not been previously established.
    • Investigating relaxin's bioactivity is crucial for understanding pregnancy physiology.

    Purpose of the Study:

    • To determine if immunoreactive relaxin in human pregnancy serum exhibits biological activity.
    • To compare the bioactivity of relaxin from pregnancy serum with that from non-pregnant serum.

    Main Methods:

    • Serum samples from pregnant women, men, and women in the follicular phase were processed.
    • Relaxin was extracted using a delipidation and acid-acetone precipitation method.
    • Extracts were tested in an in vitro rat uterine horn bioassay.

    Main Results:

    • Extracts from male and follicular-phase serum, lacking immunoreactive relaxin, caused uterine contractions.
    • Extract from pregnancy serum, containing immunoreactive relaxin, inhibited uterine contractions.
    • This study provides the first evidence of relaxin-like bioactivity in human serum.

    Conclusions:

    • Immunoreactive relaxin in human pregnancy serum is biologically active.
    • This bioactivity is characterized by the inhibition of uterine contractility.
    • The findings confirm a functional role for relaxin during human pregnancy.

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