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Updated: May 21, 2025

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration

Revathi Sampath1,2, Katherine Vaeth2, Valeryia Mikalayeva1

  • 1The Laboratory of Cell Culture, Lithuanian University of Health Sciences, Kaunas, 50103, Lithuania.

Journal of Cell Science
|March 20, 2025
PubMed
Summary

Rab40-CRL5 complexes regulate cell migration by ubiquitylating AMBRA1, a protein that controls gene transcription. This interaction reveals a new pathway for cell migration control.

Keywords:
AMBRA1Cell migrationRab40 GTPaseUbiquitylation

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