Bioinformatics analysis explores key pathways and hub genes in central precocious puberty

Area of Science:

• Pediatric Endocrinology
• Molecular Biology
• Bioinformatics

Background:

• Central precocious puberty (CPP) is a common pediatric endocrine disorder.
• The underlying molecular mechanisms of CPP development are not fully understood.

Purpose of the Study:

• To identify key molecular pathways and hub genes associated with CPP.
• To elucidate the molecular mechanisms driving CPP progression.

Main Methods:

• Analysis of two public gene expression datasets (GSE7142 and GSE8310).
• Identification of differentially expressed genes (DEGs) in CPP patients.
• Bioinformatics analyses including pathway enrichment (KEGG) and hub gene screening.

Main Results:

• Identified overlapping down-regulated DEGs between CPP and control groups across datasets.
• Revealed continuous suppression of the calcium signaling pathway in CPP.
• Highlighted the role of the MAPK signaling pathway in CPP pathogenesis.
• Screened FGFR2 and FLT1 as potential hub genes strongly associated with CPP.

Conclusions:

• The study provides novel insights into signaling pathways and candidate genes for CPP.
• FGFR2 and FLT1 represent potential targets for future CPP diagnosis and treatment strategies.
• Further validation studies are warranted to confirm these findings.