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Updated: May 21, 2025
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Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
137
The impact of cannabinoids on reproductive function.
Reproduction (Cambridge, England)
|March 20, 2025
Summary
Cannabinoid exposure before and during conception impacts reproductive health in males and females. More research is needed on THC and CBD effects on fertility and pregnancy outcomes.
Area of Science:
- Reproductive Science
- Pharmacology
- Public Health
Background:
- Global cannabis use is rising, particularly among young adults.
- Understanding the impact of cannabis constituents like THC and CBD on reproduction is crucial.
Purpose of the Study:
- To review evidence on cannabinoid exposure effects on reproductive function and pregnancy outcomes (2014-2024).
- To identify knowledge gaps concerning THC and CBD's specific reproductive contributions.
- To assess pre- or periconceptual cannabinoid exposure effects, including transgenerational impacts.
Main Methods:
- Systematic review of animal and human studies from 2014-2024.
- Focused on pre- or periconceptual exposure to cannabinoids.
- Examined effects on male reproductive function, female reproductive function, and pregnancy outcomes.
Main Results:
- Evidence suggests cannabinoid exposure can affect reproductive health.
- Specific contributions of THC and CBD require further elucidation.
- Limited data exists on long-term and transgenerational effects.
Conclusions:
- A significant need exists for preclinical and clinical studies.
- Investigating various routes and mixtures of cannabinoid exposure is essential.
- Findings are vital for clinicians and policymakers regarding cannabis safety in reproduction.
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