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[Managing the discontinuation of GLP-1 agonists : how to insure a smooth transition]
Jorge César Correia1,2, Julia Sader1, Karim Gariani2,3
1Unité d'éducation thérapeutique du patient, Centre collaborateur OMS, Service de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Glucagon-like peptide-1 receptor agonists have revolutionized the management of obesity. However, when they are discontinued, often due to reimbursement limitations, there is a high risk of weight regain. This is linked to complex biological mechanisms, including hormonal disruption, a drop in basal metabolism, and dysregulation of central reward circuits. Lasting weight loss is best achieved through a gradual transition, accompanied by professional and interdisciplinary follow-up that includes nutritional, psychological, and behavioral interventions, as well as adapted physical activity. A comprehensive approach based on therapeutic patient education is essential for maintaining long-term therapeutic benefits and preventing rebound effects.
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