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Updated: May 21, 2025
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Racial disparities in cardiovascular manifestations among patients with sickle cell trait: analysis of national
Praneeth Reddy Keesari1, Charan Thej Reddy Vegivinti2, Medha Rajamanuri3
1Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Insights
Sickle cell trait (SCT) affects millions, with African Americans disproportionately impacted. This study found higher odds of acute heart failure in African Americans with SCT, highlighting an understudied cardiovascular risk.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Public Health
Background:
- Sickle cell trait (SCT) affects millions, including 10% of African Americans in the U.S.
- SCT is often considered benign, but its full health burden and racial disparities are understudied.
- Limited data exists on cardiovascular risk in African Americans with SCT compared to other racial groups.
Purpose of the Study:
- To investigate cardiovascular outcomes in African Americans with SCT.
- To compare cardiovascular risk in African Americans with SCT versus other racial groups.
Main Methods:
- Utilized the National Inpatient Sample (NIS) database for analysis.
- Compared cardiovascular outcomes between African Americans with SCT and other racial groups.
Main Results:
- African Americans with SCT showed statistically significant higher odds of acute heart failure.
- Adjusted Odds Ratio (OR) for acute heart failure in African Americans with SCT was 1.39 (p < 0.01, 95% CI: 1.13-1.71).
Conclusions:
- African Americans with SCT may face increased cardiovascular risk, specifically for acute heart failure.
- Further research is needed to understand racial disparities and causal effects of SCT on cardiovascular health.
Abstract:
Sickle cell trait (SCT) is a condition that affects up to 3 million individuals and 10% of African Americans (AA) in the United States (U.S.). Although often believed to be benign, the true burden of the condition remains understudied. Data is also lacking regarding the racial disparities in SCT and if African American individuals with SCT are at increased cardiovascular risk compared to individuals of other races. Using the National Inpatient Sample (NIS) database, we investigated cardiovascular outcomes in AA individuals with SCT compared to other racial groups. Our study reported statistically significant higher odds of acute heart failure in AA individuals with SCT (Adjusted OR: 1.39 (p < 0.01, 95% CI: 1.13-1.71). Further studies investigating the racial disparities and cardiovascular risk among individuals with SCT are warranted to measure the causal effects.
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