Chronic Kidney Disease Increases Risk of Delayed Post-Polypectomy Bleeding: A Large-Scale Propensity Score-Matched

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Hye Kyung Hyun1, Nak-Hoon Son2, So Hyeon Gwon2

  • 1Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

United European Gastroenterology Journal
|March 20, 2025
PubMed

Insights

Patients with chronic kidney disease (CKD) face a higher risk of delayed post-polypectomy bleeding. This risk escalates with CKD severity, emphasizing the need for careful polypectomy in all CKD patients.

Area of Science:

  • Gastroenterology
  • Nephrology
  • Clinical Research

Background:

  • The relationship between chronic kidney disease (CKD) and delayed post-polypectomy bleeding (DPPB) is not well-established.
  • Understanding this association is crucial for patient safety during endoscopic procedures.

Purpose of the Study:

  • To investigate the association between CKD and the risk of DPPB.
  • To determine if CKD is an independent risk factor for DPPB.

Main Methods:

  • A large cohort study in Korea (2005-2022) analyzed patients undergoing colonoscopy and polypectomy.
  • Propensity score matching and inverse probability of treatment weighting were used to control for confounding factors.
  • Covariates included patient, polyp, and procedure-related variables.

Main Results:

  • Patients with CKD had a significantly higher risk of DPPB (OR 1.80).
  • The risk of DPPB increased with CKD stage (early stage OR 2.38, advanced stage OR 2.80).
  • Findings were robust after inverse probability weighting analysis.

Conclusions:

  • CKD is an independent risk factor for DPPB, even in early stages.
  • The risk of DPPB is stage-dependent in patients with CKD.
  • Enhanced vigilance during polypectomy is recommended for all CKD patients.
Abstract

Keywords:
bleeding risk factorschronic kidney diseasecolonoscopydelayed post‐polypectomy bleedingpolypectomypropensity score matching

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