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Imaging-Guided Microscale Photothermal Stereolithography Bioprinting
Jingyu Sun1, Tianqi Fang1, Yuze Zhang2
1Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 20, 2025
Summary
Imaging-guided microscale photothermal stereolithography bioprinting (ImPSB) overcomes limitations of costly photoinitiators. This low-cost, high-resolution technique enables advanced tissue engineering applications.
Area of Science:
- Biotechnology
- Materials Science
- Regenerative Medicine
Background:
- Stereolithography bioprinting often uses expensive photoinitiators, hindering progress in tissue engineering.
- Photothermal conversion offers a low-cost alternative, but achieving high resolution in aqueous environments is challenging.
Purpose of the Study:
- To develop a high-resolution, low-cost bioprinting method using photothermal technology.
- To address the challenge of heat confinement in aqueous environments for stereolithography bioprinting.
Main Methods:
- Established an imaging-guided stereolithography system for depth-resolved visualization.
- Developed a novel photothermal initiator for the second near-infrared window.
- Created a new bioink enabling controlled photothermal gelation.
Main Results:
- Achieved a printing resolution of approximately 47 µm.
- Generated smooth lines with a minimum cross-sectional diameter of approximately 104 µm.
- Demonstrated cellular biocompatibility and feasibility for transdermal printing.
Conclusions:
- Imaging-guided microscale photothermal stereolithography bioprinting (ImPSB) offers an unprecedented scale for photothermal aqueous stereolithography.
- This technique paves the way for utilizing photothermal resources in high-resolution bioprinting for tissue engineering and regenerative medicine.
