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Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
Published on: May 17, 2024
Sexual dimorphism in cerebrovascular dysfunction: The pivotal role of endothelial CD2AP in Alzheimer's disease
Hong Bao1, Shuxin Zheng1, Yong Shen1
1Department of Neurology and Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, China.
Abstract:
Why there is sex-biased susceptibility to cerebrovascular dysfunction remains enigmatic. Vandal et al.1 reveal a sex-specific vulnerability to endothelial deficiency in CD2AP, an Alzheimer's disease risk gene, with impaired cerebrovascular reactivity, compromised cerebrovascular function, and cognitive decline, highlighting sex as an important biological variable in Alzheimer's disease.

