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Modulation of host response by Trichinella pseudospiralis
Parasite Immunology
|May 1, 1985
Summary
Trichinella pseudospiralis infection in mice causes less muscle inflammation than Trichinella spiralis infection. Concurrent infections with both parasites also reduced inflammation, indicating a modulated host immune response.
Area of Science:
- Immunology
- Parasitology
- Veterinary Medicine
Background:
- Trichinella species are parasitic nematodes that infect various mammals.
- Host inflammatory responses are crucial in combating parasitic infections.
- Myeloperoxidase activity is a marker for inflammation.
Purpose of the Study:
- To quantify the host inflammatory response to Trichinella pseudospiralis and Trichinella spiralis infections in mice.
- To compare the inflammatory potential of T. pseudospiralis and T. spiralis, individually and concurrently.
Main Methods:
- Mice were infected with T. pseudospiralis, T. spiralis, or both helminths.
- Myeloperoxidase activity was measured in muscle tissue as an indicator of inflammation.
- Inflammation around implanted cotton string was also assessed.
Main Results:
- Mice infected with T. pseudospiralis alone exhibited less diaphragm muscle inflammation compared to those infected with T. spiralis alone.
- T. pseudospiralis infection significantly reduced inflammation around subcutaneous implanted cotton string.
- Concurrent infection with both parasites resulted in lower myositis than infection with T. spiralis alone.
Conclusions:
- Trichinella pseudospiralis induces a less intense inflammatory response in mice compared to Trichinella spiralis.
- The presence of T. pseudospiralis can modulate the host's inflammatory reaction, even in concurrent infections.