Development of hyaluronic acid-based hydrogels for chronic diabetic wound healing: A review

This research delves into the advancements in chronic skin wound treatment, with a particular focus on diabetic foot ulcers, utilizing hyaluronic acid (HA)-based hydrogels. Hyaluronic acid, an integral component of the skin's extracellular matrix, plays a crucial role in process such as inflammation, angiogenesis, and tissue regeneration. Due to their three-dimensional network structure, biocompatibility, hydrophilicity, and gas exchange capabilities, HA-based hydrogels are considered highly suitable for promoting wound healing. Nonetheless, pure HA hydrogels exhibit limitations including insufficient mechanical strength and rapid release of encapsulated substances. To address these limitations, the incorporation of bioactive materials such as chitosan and collagen was investigated. This combination not only optimized mechanical strength and degradation rates but also enhanced antibacterial and anti-inflammatory properties. Furthermore, responsive hydrogel dressings were developed to adapt to the specific characteristics of the diabetic wound microenvironment, enabling on-demand drug release. These advancements present new perspectives for the treatment of diabetic foot ulcers.