Related Experiment Video
Updated: May 21, 2025

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Hydroxylamine natural products
Roderick W Bates1, Thang Loi Pham1, Patcharaporn Sae-Lao1
1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore.
Abstract:
Natural products containing the hydroxylamine group are discussed. These include acyclic hydroxylamines, isoxazolidines, 1,2-oxazines, diketopiperazines, endocyclic hydroxylamines with larger ring sizes, N-hydroxy and N-methoxypyrroles, -indoles, -carbazoles and -carbolines, pyridones, other rings with an exocyclic hydroxylamine, O-acylhydroxylamines and compounds that may be regarded as unprecedented or having little precedent. Isolation, characterization, biosynthesis and synthesis are covered.
More Related Videos
06:18Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
12:02An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Related Concept Videos
Amines: Introduction
Preparation of Amines: Reduction of Oximes and Nitro Compounds
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Physical Properties of Amines
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...