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Updated: May 21, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Current Antifungals and the Developing Pipeline.

Melissa D Johnson1, W Justin Moore2

  • 1Division of Infectious Diseases & International Health, Duke University Medical Center, Box 102359 DUMC, Durham, NC 27710, USA.

Infectious Disease Clinics of North America
|March 20, 2025
PubMed
Summary
This summary is machine-generated.

Managing invasive fungal infections is difficult due to patient complexity and antifungal drug limitations. Understanding antifungal properties is crucial for effective treatment and prevention strategies.

Keywords:
Antifungal drugsAzolesEchinocandinsInvasive fungal infectionsNovel therapiesPipelinePolyenesReview

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive fungal infections (IFIs) pose significant challenges in clinical practice.
  • High morbidity and mortality rates associated with IFIs necessitate effective management strategies.
  • Existing antifungal agents have limitations, driving the need for improved therapeutic options.

Purpose of the Study:

  • To review key features of U.S. Food and Drug Administration-approved and pipeline antifungal agents.
  • To facilitate a better understanding of the role of antifungals in the prevention and treatment of IFIs.
  • To highlight the importance of considering drug spectrum, pharmacokinetics, toxicity, resistance, and interactions.

Main Methods:

  • Literature review of U.S. Food and Drug Administration-approved antifungal drugs.
  • Analysis of pipeline antifungal agents currently under development.
  • Synthesis of information on spectrum of activity, pharmacokinetics/pharmacodynamics, toxicity, resistance, and drug interactions.

Main Results:

  • Despite investment, an ideal antifungal agent remains elusive.
  • Clinicians require comprehensive knowledge of antifungal properties for optimal use.
  • Key features of existing and emerging antifungals are detailed to guide clinical decision-making.

Conclusions:

  • Effective prevention and management of IFIs require careful consideration of antifungal agent characteristics.
  • Awareness of drug differences is essential for optimizing treatment and minimizing resistance.
  • Continued research and development are necessary to address the unmet needs in antifungal therapy.