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Highly expressed GCN1 is associated with cancer progression and poor prognosis in hepatocellular carcinoma patients

  • 0Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430000, China.
Cancer Cell International +

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March 21, 2025

|

March 21, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

General control non-derepressible protein 1 (GCN1) is upregulated in hepatocellular carcinoma (HCC), correlating with poor prognosis. Targeting GCN1 may suppress HCC progression by regulating the Wnt signaling pathway.

Area Of Science

  • Oncology
  • Molecular Biology

Background

  • General control non-derepressible protein 1 (GCN1) is a ribosome-binding protein linked to various cancers.
  • The role of GCN1 in hepatocellular carcinoma (HCC) remains unexplored.

Purpose Of The Study

  • To investigate the expression, clinical significance, and functional role of GCN1 in HCC.
  • To explore the potential of GCN1 as a prognostic and therapeutic target for HCC.

Main Methods

  • Analysis of GCN1 expression in HCC using multiple databases and bioinformatics.
  • Correlation analysis of GCN1 with clinical features and immune infiltration.
  • Functional studies including KEGG and GSEA, and in vitro experiments with GCN1 knockdown.

Main Results

  • GCN1 is significantly upregulated in HCC, associated with adverse clinicopathological features and poorer prognosis.
  • GCN1 expression correlates with immune cell infiltration in HCC.
  • GCN1 knockdown inhibits HCC cell proliferation, invasion, and migration, impacting cell cycle and Wnt signaling pathways.

Conclusions

  • GCN1 overexpression is linked to HCC progression and poor prognosis.
  • GCN1 knockdown suppresses HCC cell growth and metastasis via the Wnt signaling pathway.
  • GCN1 presents a potential prognostic and therapeutic target for HCC.

Keywords:

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