Related Experiment Video
Updated: May 21, 2025

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Cacomalides A-G, Manoalide-Related Sesterterpenes With Anti-Inflammatory Activities From the Marine Sponge
Wenjie Zhang1, Yu Chen1, Jianing Geng1
1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China.
Abstract:
Seven previously undescribed manoalide-related sesterterpenes, named cacomalides A-G (1-7), were isolated from the marine sponge Cacosponges sp. collected in the South China Sea. The planar structures and absolute configurations of these compounds are unambiguously determined through comprehensive methods, including high-resolution electrospray ionization mass spectrometry analysis, one-dimensional and two-dimensional nuclear magnetic resonance (NMR) data analysis, empirical rules of proton (1H) and carbon-13 (13C) NMR shifts, DP4+ analysis, and electronic circular dichroism spectra. The activity testing of the compounds using zebrafish models and cacomalide A (1) exhibited anti-inflammatory activity.
More Related Videos
12:12Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays
Published on: March 29, 2022
09:49Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Symbiosis