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Oral Delivery Strategies for Biological Drugs
Huiling Zeng1,2, Mingyang Ma1,2, Xiuju Peng1,2
1Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China.
Small Methods
|March 21, 2025
Summary
Oral biologics offer improved patient compliance but face gastrointestinal challenges. Novel delivery systems, including nanoparticle-based and colon-targeted approaches, are advancing oral biologic bioavailability.
Area of Science:
- Biopharmaceutical delivery systems
- Drug bioavailability enhancement
- Gastrointestinal drug absorption
Background:
- Biologics offer advantages over small molecules due to low toxicity, high specificity, and biocompatibility.
- Oral administration of biologics enhances patient compliance but is hindered by the gastrointestinal environment.
- Current biologic administration is predominantly parenteral due to bioavailability challenges.
Purpose of the Study:
- To review physiological barriers for oral biologic delivery.
- To describe current oral biologics and delivery technologies.
- To discuss advancements in novel oral delivery systems and colon-targeted approaches.
Main Methods:
- Review of existing literature on oral biologics delivery.
- Analysis of current market and clinical trial data for oral biologics.
- Exploration of emerging technologies like nanoparticles, ionic liquids, and microneedles.
- Investigation of colon-targeted delivery strategies.
Main Results:
- Significant physiological barriers limit oral biologic bioavailability, including low pH, enzyme degradation, and poor permeability.
- Novel delivery systems such as nanoparticles, ionic liquids, and microneedles show promise.
- Colon-targeted delivery offers potential advantages due to a less hostile enzymatic environment.
Conclusions:
- Advancements in delivery technologies are crucial for overcoming oral biologic challenges.
- Further research into biologic drugs and delivery methods can unlock new opportunities for oral administration.
- Successful oral biologic delivery could revolutionize patient treatment and compliance.
Keywords:
absorptionbiological drugdrug delivery systemmembrane translationnanoparticlesoral deliveryphysiological barrierMore Related Videos
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