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The genetic association between major depressive disorder and coronary heart disease

Yue Shi1, Feikang Xu2, Yumei Wei1

  • 1Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Acta Neuropsychiatrica
|March 21, 2025
PubMed

Insights

Major depressive disorder (MDD) and coronary heart disease (CHD) share genetic links, particularly involving immune function and ribosome biogenesis. These findings suggest immune pathways may contribute to the development of both conditions.

Area of Science:

  • Genomics
  • Cardiology
  • Psychiatry

Background:

  • Major depressive disorder (MDD) and coronary heart disease (CHD) are significant causes of morbidity and mortality.
  • The established association between MDD and CHD necessitates further investigation into underlying mechanisms.

Purpose of the Study:

  • To identify shared genetic factors and pathways implicated in both MDD and CHD.
  • To explore the functional interactions of these shared genes using network analysis.

Main Methods:

  • Downloaded and analyzed seven mRNA microarray datasets for MDD and CHD patients.
  • Identified differentially expressed genes (DEGs) and constructed a protein-protein interaction (PPI) network.
  • Performed functional enrichment analyses on overlapping DEGs.

Main Results:

  • Identified 24 overlapping genes between MDD and CHD.
  • Enrichment analysis revealed associations with immune function and ribosome biogenesis.
  • Discovered three hub genes (MMP9, S100A8, RETN) and highlighted the IL-17 signaling pathway.

Conclusions:

  • MDD and CHD exhibit a genetic association.
  • Immune function genes, particularly within the IL-17 signaling pathway, may play a role in the pathogenesis of both disorders.

Keywords:
coronary heart diseasegeneticsmajor depressive disorder

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