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Modulation of Gut Microbiota Using VSL#3 and Its Impact on Aortic Parameters in a Rat Model
Mehzat Altun1, Uğur Küçük2, Nuray Yıldırım1
1Vocational School of Health Services, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.
Anatolian Journal of Cardiology
|March 21, 2025
Summary
Modulating the gut microbiome with VSL#3 improved aortic stiffness in rats. This suggests a new approach for cardiovascular disease prevention and treatment.
Area of Science:
- Cardiovascular Research
- Microbiome Science
- Animal Models
Background:
- Aortic stiffness is a key indicator of cardiovascular diseases (CVDs), representing a significant global health issue.
- Gut microbiota homeostasis plays a crucial role in the development and progression of CVDs.
Purpose of the Study:
- To investigate the impact of gut microbiota modulation on aortic parameters.
- To assess the effects of VSL#3 administration on aortic stiffness in a rat model.
Main Methods:
- Twelve male Wistar rats were divided into VSL#3-treated and control groups.
- Echocardiography was used to measure cardiac function and aortic parameters.
- Gut microbial composition was analyzed using 16S rDNA gene sequencing.
Main Results:
- Statistically significant differences in bacterial density were observed between the groups (P = .037).
- The VSL#3-treated group showed significant improvements in aortic systolic and diastolic diameters and strain parameters compared to controls.
Conclusions:
- Gut microbiome modulation via VSL#3 administration shows promise for improving aortic parameters.
- This suggests a potential novel therapeutic strategy for cardiovascular health.
