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Updated: May 21, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Base-mediated synthesis of ring-fluorinated imidazo[1,2-a]pyridines via sequential C-F substitutions
Qiuyun Li1, Tianyu Du1, Xue Feng1
1Faculty of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China. liqiuyun@ycit.edu.cn.
Abstract:
Developing innovative approaches for the synthesis of compounds that integrate imidazo[1,2-a]pyridines and fluoro fragments is crucial. Herein, an expedient [3 + 3] annulation method for synthesizing ring-fluorinated imidazo[1,2-a]pyridines via two consecutive C-F substitutions from readily available 1C,3N-dinucleophiles and β-CF3-1,3-enynes is presented. This protocol exhibits several appealing features, including readily available and inexpensive substrates, a broad range of functional groups, step and atom economy, and mild reaction conditions without any transition-metal catalysts.
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