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Updated: May 21, 2025

Measuring Lactase Enzymatic Activity in the Teaching Lab
Published on: August 6, 2018
Blocking lactate: kick T cells when they are down
Veronika Horkova1,2, Bart Everts3, Dirk Brenner1,2,4
1Experimental and Molecular Immunology, Department of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Abstract:
In the last couple of decades, cancer research has been shifting its focus to the immune system. Cancer cells, with their ability to adapt and evade immune responses, seem to accelerate the evolutionary pressure that has been put on our immune system during evolution. We thus try to aid these natural selection processes and assist our immune system to combat cancer. Here, we are discussing a study by Greg Delgoffe and colleagues that was published in Nature Immunology in December 2024, exploring a new approach to bring the dysfunctional immune cells back to life by blocking their lactate uptake.
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