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Acquired cutis laxa: case report and review of disorders of elastolysis
Pediatric Dermatology
|July 1, 1985
Insights
A 10-year-old boy developed acquired cutis laxa during isoniazid treatment. This case highlights a potential drug-induced elastolysis syndrome, distinct from inherited or neonatal forms.
Area of Science:
- Dermatology
- Genetics
- Pharmacology
Background:
- Cutis laxa is a rare connective tissue disorder characterized by elastic tissue degeneration.
- It can be inherited, present neonatally, or be acquired later in life.
- Isoniazid is a common antitubercular drug with known side effects.
Observation:
- A 10-year-old boy developed generalized cutis laxa.
- The onset of cutis laxa coincided with isoniazid therapy.
- No other systemic manifestations were noted.
Findings:
- This case suggests isoniazid-induced acquired cutis laxa.
- The patient's condition represents a form of drug-induced elastolysis.
- This presentation is distinct from inherited and neonatal cutis laxa.
Implications:
- This case expands the understanding of acquired cutis laxa etiologies.
- It suggests the need for vigilance regarding potential skin side effects of isoniazid.
- A proposed classification of elastolysis syndromes is presented, including acquired forms.
Abstract:
A 10-year-old boy developed cutis laxa while receiving isoniazid therapy; no systemic manifestations occurred. There are several well-documented cases of acquired cutis laxa. We propose a classification of the elastolysis syndromes, including inherited, neonatal, and acquired forms of cutis laxa.