Elevated lipoprotein(a) and cardiovascular outcomes in prediabetes and diabetes: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated lipoprotein(a) [Lp(a)] significantly increases atherosclerotic cardiovascular disease (ASCVD) risk in diabetics and pre-diabetics. Higher Lp(a) levels correlate with greater ASCVD event occurrence in these populations.
Area Of Science
- Cardiology
- Endocrinology
- Genetics
Background
- Elevated lipoprotein(a) [Lp(a)] and diabetes are recognized risk factors for coronary artery disease (CAD).
- This study examines the impact of varying Lp(a) levels on atherosclerotic cardiovascular disease (ASCVD) events in individuals with and without diabetes.
Purpose Of The Study
- To investigate the association between different lipoprotein(a) [Lp(a)] levels and the risk of atherosclerotic cardiovascular disease (ASCVD) events.
- To compare these risks in individuals with diabetes, prediabetes, and normal glucose levels.
Main Methods
- A systematic review and meta-analysis of retrospective studies published in English until May 2023.
- Inclusion criteria focused on studies examining Lp(a) levels and cardiovascular outcomes in humans with diabetes, prediabetes, or normal glucose levels.
- Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using binary random-effects models, with heterogeneity assessed by I² statistics.
Main Results
- Analysis of three studies included 20,271 patients.
- Compared to non-diabetics with Lp(a) <10 mg/dL, ASCVD risk increased with higher Lp(a) levels in pre-diabetics (HRs ranging from 1.40 to 2.08) and diabetics (HRs ranging from 2.42 to 4.17).
- All observed increases in risk were statistically significant (P<0.01).
Conclusions
- High lipoprotein(a) [Lp(a)] levels (>30 mg/dL) are significantly associated with an increased incidence of ASCVD events in both diabetic and pre-diabetic individuals.
- These findings highlight the clinical significance of Lp(a) in refining risk stratification and guiding therapeutic interventions for cardiovascular disease in glucose-impaired populations.
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