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Related Experiment Video

Updated: May 21, 2025

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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Coronary microvascular dysfunction and right ventricular structure and function.

Amélie Paquin1,2, Michael D Nelson1,3, Janet Wei1

  • 1Barbra Streisand Women's Heart Center, Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.

Cardiovascular Diagnosis and Therapy
|March 21, 2025
PubMed
Summary
This summary is machine-generated.

Coronary microvascular dysfunction (CMD) did not show a link with right ventricular (RV) structure or function in patients with suspected ischemia and no obstructive coronary artery disease. Further studies are needed to explore long-term effects.

Keywords:
Right ventriclecardiac magnetic resonancecoronary microvascular dysfunction (CMD)coronary provocative testingischemia and no obstructive coronary artery (INOCA)

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Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Vascular Physiology

Background:

  • Coronary microvascular dysfunction (CMD) is linked to left ventricular (LV) changes, but its effect on the right ventricle (RV) is less understood.
  • Potential RV involvement in CMD may stem from ischemia, shared pathophysiology, or increased afterload due to LV dysfunction or pulmonary hypertension.
  • Investigating RV structure and function in the context of CMD is crucial for a comprehensive understanding of cardiovascular health.

Purpose of the Study:

  • To evaluate the relationship between right ventricular (RV) structure and function and invasively measured coronary microvascular dysfunction (CMD).
  • To assess correlations between cardiac magnetic resonance imaging (CMRI) derived RV parameters and coronary microvascular function in patients with suspected ischemia and no obstructive coronary artery (INOCA) disease.

Main Methods:

  • Utilized data from 297 participants in the WISE-HFpEF, WISE-preHFpEF, and WISE-CVD cohorts.
  • Conducted cardiac magnetic resonance imaging (CMRI) for RV structure and function assessment.
  • Performed invasive coronary function testing to measure coronary flow reserve (CFR) and coronary blood flow change (∆CBF) in response to adenosine and acetylcholine, respectively.

Main Results:

  • No significant correlation was found between RV parameters (e.g., RV end-diastolic volume, RV ejection fraction, RV longitudinal strain) and measures of coronary microvascular function (CFR, ∆CBF).
  • This study is the first to report on the association between invasively measured CMD and CMRI-assessed RV parameters in patients with suspected INOCA.
  • Despite a substantial sample size, the findings indicate no concurrent relationship between RV abnormalities and CMD in this population.

Conclusions:

  • Right ventricular structure and function do not appear to be concurrently affected by or precede coronary microvascular dysfunction in individuals with suspected INOCA.
  • Further longitudinal studies are warranted to determine if RV deterioration develops later in the course of CMD or in patients with heart failure with preserved ejection fraction (HFpEF).
  • The findings highlight the need for further research into the long-term sequelae of CMD on RV health.