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Association between albumin-corrected calcium and all-cause mortality in patients with heart failure: a retrospective

Xiongda Yao1, Yurong Leng2, Junda Cao3

  • 1Department of Cardiology, Jiangxi Medical College, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.

Frontiers in Cardiovascular Medicine
|March 21, 2025
PubMed

Insights

Albumin-corrected calcium (ACC) levels show a U-shaped association with mortality in heart failure (HF) patients. Elevated ACC is linked to increased 30- and 180-day mortality, suggesting its use as a prognostic marker.

Area of Science:

  • Cardiology
  • Clinical Biochemistry
  • Public Health

Background:

  • Heart failure (HF) is a significant cause of mortality in hospitalized patients globally.
  • Accurate prognostic evaluation is crucial for effective HF management.
  • The role of albumin-corrected calcium (ACC) in HF prognosis requires further investigation.

Purpose of the Study:

  • To investigate the association between albumin-corrected calcium (ACC) levels and mortality in hospitalized heart failure patients.
  • To determine if ACC can serve as a prognostic indicator in this population.

Main Methods:

  • Retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.
  • Stratification of patients into three groups based on ACC levels.
  • Analysis using Cox proportional hazards regression and restricted cubic spline models.

Main Results:

  • A total of 4,737 heart failure patients were analyzed.
  • Elevated ACC levels were significantly associated with increased 30-day and 180-day mortality.
  • A U-shaped relationship between ACC and mortality was observed, with an inflection point at 9.18. ACC > 9.18 increased 30-day mortality risk by 20.4% and 180-day mortality risk by 20.8%.

Conclusions:

  • A U-shaped association exists between ACC levels and mortality in heart failure patients.
  • ACC may serve as a valuable prognostic marker for short-term and mid-term mortality in hospitalized HF patients.
  • Further research can explore the clinical utility of ACC monitoring in HF management.
Abstract

Keywords:
MIMIC-IV databasealbumin-corrected calciumall-cause mortalitycalciumheart failure

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