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Hemostasis and Gingival Healing-Polyurethane Adhesive Postextraction Under Rivaroxaban Therapy in a Rodent Model.
Marius Heitzer1, Philipp Winnand1, Marie Sophie Katz1
1Department of Oral and Cranio-Maxillofacial Surgery, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany.
International Journal of Dentistry
|March 21, 2025
Summary
This study compared a new adhesive, VIVO, to gelatin sponge (GESP) for controlling bleeding after tooth extraction in rodents on rivaroxaban. VIVO demonstrated shorter postoperative bleeding times, suggesting better hemostasis for patients on anticoagulants.
Area of Science:
- Oral Surgery
- Biomaterials Science
- Pharmacology
Background:
- Postoperative bleeding after tooth extraction is a significant risk (31%) for patients on rivaroxaban.
- Effective hemostatic agents are crucial for managing bleeding in these high-risk patients.
Purpose of the Study:
- To compare the hemostatic properties and gingival healing of a novel polyurethane-based adhesive (VIVO) versus gelatin sponge (GESP).
- To evaluate these agents in a rodent model under continuous rivaroxaban therapy over 10 days.
Main Methods:
- 120 first upper molar extractions were performed in rivaroxaban-treated rodents.
- 60 extraction sites were treated with VIVO, and 60 with GESP.
- Surgical duration, bleeding, wound healing, in vivo fluorescence imaging, and laser Doppler flowmetry/tissue spectrophotometry (LDF-TS) were assessed.
Main Results:
- VIVO demonstrated significantly shorter postoperative bleeding times (1:39 min) compared to GESP (1:06 min).
- Both treatments showed comparable, non-significant mild bleeding events and wound healing scores.
- LDF-TS indicated increased oxygen saturation and blood flow with both agents; only GESP showed increased relative hemoglobin.
Conclusions:
- VIVO exhibited favorable hemostasis in rodent tooth extraction sockets under rivaroxaban therapy.
- The novel adhesive shows promise for managing bleeding and promoting healing in patients on anticoagulants.
