Hemostasis and Gingival Healing-Polyurethane Adhesive Postextraction Under Rivaroxaban Therapy in a Rodent Model

Objectives: At 31%, the risk of postoperative bleeding after tooth extraction is particularly high in patients who receive rivaroxaban therapy. The aim of this rodent study was to compare the hemostyptic properties and gingival healing between novel polyurethane-based adhesive VIVO and gelatin sponge (GESP) under ongoing rivaroxaban therapy over a period of 10 days. Materials: In total, 120 extractions of the first upper molar were proceeded in rodents treated with rivaroxaban. Of these, 60 postextraction sites were treated with VIVO and 60 with GESP. The duration of the surgical procedure and the clinical parameters of postoperative bleeding and wound evaluation score were recorded. In vivo fluorescence imaging and laser Doppler flowmetry and tissue spectrophotometry (LDF-TS) were performed. Results: GESP provided a faster procedure at 1:06 ± 0:17 min, but postoperative bleeding time was significantly shorter in VIVO sockets at 1:39 ± 0:03 min. Nonsignificant mild bleeding events and comparable wound evaluation scores were recorded in both treatments. LDF-TS showed a significant increase in mean oxygen saturation SO₂ (%) and mean blood flow (AU) for both treatments. Only GESP showed a significant increase in relative hemoglobin (rHb). Conclusion: In the context of a rodent study, VIVO showed favorable hemostasis and promising gingival healing properties postextraction under ongoing rivaroxaban therapy.