Related Experiment Video
Updated: May 21, 2025
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
5.3K
Monomorphic Epitheliotropic Intestinal T-cell Lymphoma With Initial Pulmonary Symptoms: A Case Report
Amy Yeung1, TaeHoon Kim1, Jason Suh2
1Department of Internal Medicine, Valley Health System/Icahn School of Medicine at Mount Sinai, Paramus, USA.
Cureus
|March 21, 2025
Summary
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) can present with rare lung involvement alongside gastrointestinal symptoms. Early diagnosis through biopsy is crucial for this aggressive T-cell lymphoma.
Area of Science:
- Oncology
- Hematology
- Gastroenterology
Background:
- Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive T-cell neoplasm.
- It predominantly affects the small intestine, with limited data on extraintestinal manifestations.
Observation:
- A 60-year-old woman presented with respiratory symptoms (dyspnea, cough, hemoptysis) and subsequent gastrointestinal issues.
- Imaging revealed cavitary lung masses, and endoscopic evaluation showed duodenal nodularity and gastric ulcers.
Findings:
- Biopsies confirmed MEITL with a specific immunophenotype: TCR-delta+, CD8+, CD56+, and CD103+.
- Colonoscopy revealed diffuse colonic inflammation, indicating widespread disease.
Implications:
- This case highlights rare pulmonary involvement in MEITL, expanding knowledge of its extraintestinal spread.
- Clinicians should consider MEITL in patients with concurrent pulmonary and GI symptoms, necessitating prompt biopsy for diagnosis and treatment.
Related Concept Videos
01:31Pulmonary Tuberculosis III
283
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
283
01:28Pulmonary Tuberculosis II
202
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
202
01:26Pulmonary Tuberculosis IV
127
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
127