Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Bone Cells and Tissue

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatially Decoupled Sulfur Redox and Li<sup>+</sup> Transport in Polymer Electrolytes for Solid-State Li-S Batteries.

Nano letters·2026

Same author

Reciprocal repulsions enforce heterotypic dendrite segregation in an olfactory circuit.

bioRxiv : the preprint server for biology·2026

Same author

A comprehensive review of ultrasonographic imaging in athletic elbow injuries: a compartment-based approach.

Skeletal radiology·2026

Same author

Investigating the Neuroprotective Effects of Peripheral Nerve Microcurrent Stimulation in a Mouse Model of Parkinson's Disease.

Brain & NeuroRehabilitation·2026

Same author

Shape-Memory Collagen/Silk-Fibroin Scaffold for Dura Sealing and Skull Base Regeneration.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Tabula Sapiens reveals the non-coding RNA landscape across 22 human organs and tissues.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

3D bioprinted multi-layered cell constructs with gradient core-shell interface for tendon-to-bone tissue

WonJin Kim¹, Dong Rak Kwon², Hyeongjin Lee³

¹Department of Precision Medicine, Sungkyunkwan University School of Medicine (SKKU-SOM), Suwon, 16419, Republic of Korea.

Bioactive Materials

|March 21, 2025

Summary

This summary is machine-generated.

This study introduces a novel bioprinting method for rotator cuff tears, creating engineered tendon-to-bone tissue. The approach successfully regenerated complex tissues, improving healing and integration in animal models.

Keywords:

Bioprinting Complex cell-construct Tendon-bone interface Tissue engineering

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Related Experiment Videos

Last Updated: Jun 12, 2026

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Rotator cuff tears are prevalent in active individuals, often necessitating surgery due to poor natural healing.
Current treatments face limitations in fully restoring native tendon-to-bone complexity and function.

Purpose of the Study:

To develop a bioprinting strategy for fabricating engineered tendon-to-bone complex tissues.
To create a gradient interface mimicking the native tendon-bone junction for enhanced integration.
To evaluate the in vitro and in vivo efficacy of the bioprinted constructs for rotator cuff regeneration.

Main Methods:

Utilized decellularized extracellular matrix bioinks with hydroxyapatite and TGF-β/poly(vinyl alcohol).
Employed a core-shell nozzle bioprinting system for simultaneous fabrication of aligned tendon, gradient interface, and bone regions.
Assessed construct performance using human adipose stem cells in vitro and a rabbit rotator cuff tear model in vivo.

Main Results:

Achieved directed differentiation of stem cells towards osteogenic and tenogenic lineages.
Demonstrated enhanced fibrocartilage formation and tendon-bone integration in vitro with graded interface constructs.
Observed significant regeneration of full-thickness tendon-to-bone tissue, including a high-quality interface, improved mechanical properties, angiogenesis, and ECM formation in vivo.

Conclusions:

The proposed bioprinting approach effectively regenerates complex tendon-to-bone tissues.
The gradient interface design is crucial for superior tissue integration and healing.
This platform shows significant potential for treating rotator cuff injuries and other musculoskeletal defects.