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The role of TMSB15A in gastric cancer progression and its prognostic significance.

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Thymosin beta15 (TMSB15A) is overexpressed in gastric cancer (GC) and linked to poor survival. Reducing TMSB15A inhibits GC cell growth and metastasis, suggesting it as a therapeutic target.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Human thymosin beta15 (TMSB15A) exhibits protumorigenic effects in various cancers, but its role in gastric cancer (GC) is not well understood.
  • This study aimed to elucidate the diagnostic value and functional role of TMSB15A in GC tumorigenesis.

Purpose of the Study:

  • To investigate the diagnostic accuracy of TMSB15A in gastric cancer.
  • To determine the prognostic significance of TMSB15A in GC patients.
  • To explore the functional role of TMSB15A in GC cell proliferation, migration, and invasion.

Main Methods:

  • Analyzed TMSB15A expression in GC tissues using The Cancer Genome Atlas (TCGA).
  • Evaluated prognostic value via Kaplan-Meier, ROC curves, and Cox regression.
  • Performed Gene Set Enrichment Analysis (GSEA) to identify associated pathways.
  • Conducted in vitro assays to assess the impact of TMSB15A knockdown on GC cells.

Main Results:

  • TMSB15A was significantly overexpressed in GC tissues and demonstrated high diagnostic accuracy (AUC=0.851).
  • High TMSB15A expression correlated with poor overall survival, disease-specific survival, and progression-free survival.
  • TMSB15A levels were associated with advanced tumor stage, lymph node metastasis, and perineural invasion.
  • GSEA revealed enrichment in inflammatory and oncogenic pathways (IL-6/JAK/STAT3, TGF-β, Hedgehog).
  • Knockdown of TMSB15A significantly reduced GC cell proliferation, migration, and invasion.

Conclusions:

  • TMSB15A is a potential diagnostic biomarker for gastric cancer.
  • Overexpression of TMSB15A promotes GC progression and metastasis.
  • TMSB15A represents a promising therapeutic target for gastric cancer treatment.