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Updated: May 21, 2025

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Cabergoline Use and Pregnancy Outcomes: A Systematic Review.

Anne-Sophie Otis1,2, Marie-Sophie Brochet1,2,3, Zoë Tremblay1,2

  • 1Department of Pharmacy, CHU Sainte-Justine, Montreal, Quebec, Canada.

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|March 21, 2025
PubMed
Summary
This summary is machine-generated.

Cabergoline use during pregnancy shows no increased risk of major malformations or spontaneous abortions. Further high-quality studies are needed to confirm the safety of cabergoline in pregnancy.

Keywords:
cabergolinecongenital abnormalitiesdopamine agonistsovarian hyperstimulation syndromeprolactinomaspontaneous abortion

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Area of Science:

  • Reproductive medicine
  • Pharmacology
  • Obstetrics

Background:

  • Clinicians often discontinue cabergoline during pregnancy due to lack of guidelines, opting for poorly tolerated bromocriptine.
  • This practice stems from bromocriptine's more common use in pregnancy, despite its adverse effects.

Purpose of the Study:

  • To evaluate pregnancy outcomes, specifically major malformations and spontaneous abortions, following first-trimester cabergoline exposure.
  • To compare these outcomes against other treatments or no treatment during pregnancy.

Main Methods:

  • A systematic review of Embase, Pubmed, Google Scholar, and ClinicalTrials.gov was conducted.
  • Studies published before October 27, 2022, assessing cabergoline's effect on malformations and abortions were included.
  • Two independent reviewers screened and selected 30 articles from 2186 identified records.

Main Results:

  • The review included 1662 pregnancies exposed to cabergoline.
  • No increased risk of congenital malformations or spontaneous abortions was found with cabergoline compared to controls.
  • Study quality was generally low with significant heterogeneity observed.

Conclusions:

  • Cabergoline use in pregnancy did not demonstrate a negative impact on major malformations or spontaneous abortions.
  • High-quality research is necessary to further establish the safety profile of cabergoline during gestation.