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Cabergoline Use and Pregnancy Outcomes: A Systematic Review
Anne-Sophie Otis1,2, Marie-Sophie Brochet1,2,3, Zoë Tremblay1,2
1Department of Pharmacy, CHU Sainte-Justine, Montreal, Quebec, Canada.
Birth Defects Research
|March 21, 2025
Summary
Cabergoline use during pregnancy shows no increased risk of major malformations or spontaneous abortions. Further high-quality studies are needed to confirm the safety of cabergoline in pregnancy.
Area of Science:
- Reproductive medicine
- Pharmacology
- Obstetrics
Background:
- Clinicians often discontinue cabergoline during pregnancy due to lack of guidelines, opting for poorly tolerated bromocriptine.
- This practice stems from bromocriptine's more common use in pregnancy, despite its adverse effects.
Purpose of the Study:
- To evaluate pregnancy outcomes, specifically major malformations and spontaneous abortions, following first-trimester cabergoline exposure.
- To compare these outcomes against other treatments or no treatment during pregnancy.
Main Methods:
- A systematic review of Embase, Pubmed, Google Scholar, and ClinicalTrials.gov was conducted.
- Studies published before October 27, 2022, assessing cabergoline's effect on malformations and abortions were included.
- Two independent reviewers screened and selected 30 articles from 2186 identified records.
Main Results:
- The review included 1662 pregnancies exposed to cabergoline.
- No increased risk of congenital malformations or spontaneous abortions was found with cabergoline compared to controls.
- Study quality was generally low with significant heterogeneity observed.
Conclusions:
- Cabergoline use in pregnancy did not demonstrate a negative impact on major malformations or spontaneous abortions.
- High-quality research is necessary to further establish the safety profile of cabergoline during gestation.
Keywords:
cabergolinecongenital abnormalitiesdopamine agonistsovarian hyperstimulation syndromeprolactinomaspontaneous abortionMore Related Videos
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