Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)

Area of Science:

• Reproductive Biology
• Molecular Endocrinology
• Male Infertility Research

Background:

• Spermatogenesis dysfunction involves abnormal sperm parameters and seminiferous tubule damage.
• Key contributing factors include inflammation, oxidative stress, endoplasmic reticulum (ER) stress, and obesity.
• Insulin-like growth factor 2 (IGF2) has been implicated in these pathological processes.

Purpose of the Study:

• To review the relationship between IGF2 and factors contributing to spermatogenesis dysfunction.
• To explore the role of IGF2 in inflammation, oxidative stress, ER stress, and obesity.
• To provide evidence for IGF2's potential in managing male infertility.

Main Methods:

• Literature review of existing theoretical and experimental studies.
• Analysis of the connection between IGF2 and spermatogenesis dysfunction markers.
• Synthesis of data on IGF2's influence on inflammation, oxidative stress, ER stress, and obesity.

Main Results:

• IGF2 is closely associated with inflammation, oxidative stress, ER stress, and obesity.
• These conditions are significant drivers of spermatogenesis dysfunction.
• Evidence suggests IGF2 modulates these factors, impacting sperm health.

Conclusions:

• IGF2 is a critical factor in the pathogenesis of male infertility.
• Targeting IGF2 may offer a novel therapeutic strategy for spermatogenesis dysfunction.
• Further research is warranted to elucidate IGF2's precise mechanisms in male reproductive health.