[The pharmacokinetics of cephalothin following single and repeated administration in man]

The repeated administration of substances, which are mainly excreted by tubular secretion, can cause an increase of its own elimination. Because cephalothin is tubularly transported, it was of interest to prove, whether or not the repeated administration of therapeutic doses for 5 d produces an increases of renal elimination. Pharmacokinetic parameters show only small differences between the single and repeated dosing, caused by changes of volume of distribution. No stimulation of the carrier transport system was found. On the contrary, the renal elimination was reduced slightly after therapy for 5 d. Our results show that the present dosage recommendations are valid also for repeated administrations.