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Updated: May 21, 2025

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Influence of imidazole functionalization on the properties of small molecule models of the LPMO active site
Ugo Gilbert1, Xiao Mu1, Yan Yu Sarah Lam1
1Molecular Chemistry, Materials and Catalysis Division, Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1, Louvain-la-Neuve, 1348, Belgium. m.singleton@uclouvain.be.
Abstract:
A series of small molecule Cu(II) complexes based on tridentate N3 ligands relevant to the histidine brace of the active site of lytic polysaccharide monooxygenase were synthesized and characterized by X-ray crystallography and spectroscopic studies. In order to better understand the role of different structural features and to help bridge the differences between previously reported models, the methylation patterns, imidazole connectivity, linker nature, and type of heterocycle were systematically varied across the series. These modifications lead to important differences in the electrochemical properties of the complexes and their reactivity towards the oxidation of a model substrate.
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